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Cyclopryrrolone hypnotic. Short-term (i.e. 7-10 consecutive days) insomnia therapy. Use for more than 2-3 consecutive weeks requires complete re-evaluation of the patient. Adults, 7.5 mg just before retiring for the night. Geriatrics, patients with impaired liver function or chronic respiratory insufficiency: 3.75-7.5 mg at bedtime, depending on acceptability and efficacy.
Myasthenia gravis, sleep apnea syndrome, severe hepatic insufficiency, previous paradoxical reactions to alcohol and/or sedative medications.
Not recommended in pregnant or nursing women. Safety-efficacy in patients 18 years of age not established. Use with caution in patients with a history of substance or alcohol abuse, impaired renal or hepatic functions, severe pulmonary insufficiency, a history of seizures j(avoid abrupt zopiclone withdrawal), depression, elderly and/or debilitated patients.
Bitter taste. Somnolence, confusion, anterograde amnesia or memory impairment, asthenia, euphoria, depression, bad breath, coated tongue.
Hepatic enzyme-inhibiting agents (e.g. Cimetidine, crythromycin) and other CNS-depressant drugs may enhance zopiclone`s activity.
Warn against concomitant use of alcohol or other CNS-depressant drugs. Caution re drowsiness (NB driving).
7.5 mg tablets.
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