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Gastrointestinal Side Effects
The most common side effects of Brufen are gastrointestinal in nature and occur in approximately 4 to 16 percent of users. Bufren has the potential to irritate the digestive system, causing pain, diarrhea and nausea. Taking Bufren with food helps to limit the effect of the drug upon your gastrointestinal system. Other possible gastrointestinal side effects of Bufren include heartburn, vomiting, indigestion, constipation, bloating and flatulence.

Other Side Effects
Brufen also has the potential to cause a number of other troublesome or annoying, but not dangerous, side effects. Neurological and psychological side effects of the drug include headaches, dizziness, depression, confusion, tingling in your extremities, drowsiness and ringing in your ears. Some patients experience itchy skin rashes, temporary hair loss and increased sensitivity to the sun while taking Brufen. Other possible side effects of Brufen are dry eyes, mouth ulcers, loss of appetite and a runny nose.

Drug Interactions
There are some medications that produce unwanted side effects when used in conjunction with Brufen. When combined with blood thinners like Warfarin, Brufen increases your risk of experiencing uncontrollable bleeding during surgery or following an injury. Taking Brufen with lithium or methotrexate often causes a toxic build-up of the medications in your body, increasing your risk for developing serious adverse reactions. Additionally, combining Brufen with diuretics has the potential to cause damage to your kidneys.

In addition to minor side effects and the risk of interactions, Brufen has the potential to cause serious medical complications. Long term use of Brufen leads to hypertension, congestive heart failure, stroke, heart attack and blood clots in some patients. Some patients develop gastrointestinal bleeding or ulcers while using the drug. Additionally, Brufen infrequently causes kidney and liver failure. Other rare complications associated with the drug include loss of vision, inflammation of the fluid around your brain or aseptic meningitis, and severe skin infections, such as Stevens-Johnsons Syndrome or toxic epidermal necrosis.

Because there is not yet sufficient evidence that Brufen has no unwanted effects upon the fetus, doctors typically do not prescribe the drug for pregnant women. Additionally, serious side effects of Brufen are most common in people over the age of 65. If you have a history of peptic ulcers, heart failure, colitis, kidney or liver disease, stroke or diabetes, your doctor may not prescribe Brufen. Smoking while taking Bufren increases your risk for developing cardiovascular side effects.

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