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Cerviprime 30gm

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Cerviprime from AstraZeneca contains Dinoprostone
Below are some of the details of Dinoprostone(generic)

Dinoprostone causes induction of uterine muscle contraction during pregnancy. It is both a vasoconstrictor and bronchodilator. The pattern of uterine contraction is similar to that in normal labour at term. It can also stimulate the smooth muscle of the GI tract.
Onset: 10 min.
Duration: 2-3 hr (vaginal supp).
Absorption: Small amounts absorbed by the uterus.
Distribution: Diffuses into the maternal blood.
Metabolism: Hepatic, renal, spleen and other tissues: Rapid.
Excretion: Urine; faeces (small amounts).
Dinoprostone Indications / Dinoprostone Uses
Information Not Available
Dinoprostone Adverse Reactions / Dinoprostone Side Effects
Hypersensitivity reactions, nausea, vomiting, diarrhoea, abdominal pain; flushing, shivering, headache, dizziness; hypertension; convulsions, ECG changes,local tissue irritation, erythema; pyrexia, increased WBC. Uterine contractile abnormalities with or without foetal distress. Dosage >0.5 mg intracervically can cause hypertonic uterine contractions. Intra/extra-amniotic inj: Local infection, vomiting, diarrhoea, pyrexia, transient hypotension.
Potentially Fatal: Sudden CV collapse due to accidental IV absorption and intra-amniotic inj. Uterine rupture, amniotic fluid embolism during labour. Foetal distress and death in rare cases.

Rigors, vomiting, severe abdominal pain, uterine hypercontractility and uterine hypertonus. Management: conservative management may be sufficient in most cases. ??-adrenergic drugs may be used as a treatment of hyperstimulation following admin for cervical ripening.

Special Precautions
Raised intraocular pressure. Previous caesarean section; history of asthma, epilepsy, hepatic or renal dysfunction, cardiovascular disease; pregnancy.

Cervical priming, induction and augmentation of labour
Adult: As cervical gel: Apply 500 mcg in 2.5 mL preparation. May be repeated after 6 hr if necessary. Max: 1.5 mg/24 hr.
Labour induction
Adult: As vaginal gel: 1 mg (or 2 mg for primigravid patients with unfavourable induction features) followed by another 1 or 2 mg after 6 hr if necessary. Max: 3 mg (or 4 mg in unfavourable primigravid patients). As pessary: Initially, 3 mg followed by a further 3 mg after 6-8 hr if necessary. Max: 6 mg.
Pregnancy termination in the 2nd trimester
Adult: As 100 mcg/mL soln: Instill 1 mL through a suitable foley catheter followed by 1-2 mL at 2-hr intervals according to patient's response.

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