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Atenolol is a selective ??1 receptor antagonist, a drug belonging to the group of ??-blockers, a class of drugs used primarily in Cardiovascular diseases. Introduced in 1976, atenolol was developed as a replacement for propranolol in the treatment of hypertension. The chemical works by slowing down the heart and reducing its workload. Unlike propranolol, atenolol does not pass through the blood-brain barrier thus avoiding various CNS side effects.
Whilst atenolol, the most widely used ??-blocker in the United Kingdom, was once first-line treatment for hypertension, the role for ??-blockers in hypertension was downgraded in June 2006 in the United Kingdom to fourth-line as they perform less well than other drugs, particularly in the elderly, and there is increasing evidence that the most frequently used ??-blockers at usual doses carry an unacceptable risk of provoking type 2 diabetes.
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