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Atpark
Atpark from Pfizer contains Atenolol.
Below are some of the details of Atenolol(generic)
Atenolol is a selective ??1 receptor antagonist, a drug belonging to the group of ??-blockers, a class of drugs used primarily in Cardiovascular diseases. Introduced in 1976, atenolol was developed as a replacement for propranolol in the treatment of hypertension. The chemical works by slowing down the heart and reducing its workload. Unlike propranolol, atenolol does not pass through the blood-brain barrier thus avoiding various CNS side effects.
Whilst atenolol, the most widely used ??-blocker in the United Kingdom, was once first-line treatment for hypertension, the role for ??-blockers in hypertension was downgraded in June 2006 in the United Kingdom to fourth-line as they perform less well than other drugs, particularly in the elderly, and there is increasing evidence that the most frequently used ??-blockers at usual doses carry an unacceptable risk of provoking type 2 diabetes.

Atenolol Indications / Atenolol Uses
In angina pectoris, as prophylaxis of migraine and in hypertension

Atenolol Adverse Reactions / Atenolol Side Effects
Bronchospasm; cold extremities, fatigue, dizziness, insomnia, lethargy, confusion, headache, depression, nightmares, nausea, diarrhoea, constipation, impotence and paraesthesia.
Potentially Fatal: Heart failure, 2nd or 3rd degree AV block.

Precautions
Overdosage: Symptoms include lethargy, sinus pause, bradycardia, hypotension, bronchospasm and/or hypoglycaemia. Unabsorbed drug may be removed by induced emesis, gastric lavage or admin of activated charcoal.

Special Precautions
Compensated heart failure. Variant angina, acute MI, DM; peripheral vascular disorders; hepatic and renal dysfunction; elderly patients, children. Lactation. If atenolol and clonidine are co-admin, then gradual withdrawal of clonidine should take place a few days after withdrawal of atenolol.

Other Drug Interactions
Decreased effect with aluminum and calcium salts, barbiturates, cholestyramine, NSAIDs, ampicillin, rifampicin.
Potentially Fatal: May increase effects of drugs which slow AV conduction (digoxin, verapamil, diltiazem).

Other Interactions
Information Not Available

Dosage
Oral
Hypertension
Adult: 25-100 mg daily as a single dose, depending on response. Takes 1-2 wk for full effect to be observed.
Oral
Angina pectoris
Adult: 50-100 mg daily given as single or divided doses. Max dose: 200 mg daily.
Oral
Migraine prophylaxis
Adult: 50-100 mg daily.
Intravenous
Emergency treatment of cardiac arrhythmias
Adult: 2.5 mg injected at a rate of 1 mg/minute, may repeat every 5 minutes if needed. Max: 10 mg. Alternatively, 150 mcg/kg to be infused over 20 minutes. May repeat Inj or infusion procedure every 12 hr as needed. Once control is achieved, maintain with oral doses of 50-100 mg/day.
Intravenous
Acute myocardial infarction
Adult: To be given within 12 hr of the onset of chest pain. Inject 5-10 mg slowly at a rate of 1 mg/minute, followed by an oral dose of 50 mg 15 minutes later (if no adverse effects result from the inj). Alternatively, repeat an IV dose of 5 mg 10 minutes after the initial doser followed by an oral dose of 50 mg 10 minutes after the last IV dose. A further oral dose of 50 mg may be given 12 hr later. Thereafter, maintain with 50 mg every 12 hr or 100 mg/day for 6-9 days post-MI.

Food(before/after)
May be taken with or without food

List of Contraindications
Atenolol and Pregnancy
Contraindicated in pregnancy
Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Atenolol and Lactation
Caution when used during lactation
Atenolol and Children
Information Not Available
Atenolol and Geriatic
Information Not Available
Atenolol and Other Contraindications
Hypersensitivity. Sinus bradycardia, sinus node dysfunction, heart block >1st degree, compensated cardiac failure, cardiogenic shock, bronchospastic diseases, peripheral vascular diseases. Pregnancy.

Storage
Intravenous: Store at 20-25????C. Oral: Store at 20-25????C

Lab interference
Increased glucose levels, decreased HDL

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