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Cardilate is a non-selective beta-adrenergic antagonist (beta-blocker) which possesses intrinsic sympathomimetic activity (ISA) in therapeutic dosage ranges but does not possess quinidine-like membrane stabilizing activity. Cardilate impairs AV node conduction and decreases sinus rate and may also increase plasma triglycerides and decrease HDL-cholesterol levels. Cardilate is nonpolar and hydrophobic, with low to moderate lipid solubility. Cardilate has little to no intrinsic sympathomimetic activity and, unlike some other beta-adrenergic blocking agents, Cardilate has little direct myocardial depressant activity and does not have an anesthetic-like membrane-stabilizing action.
For the management of hypertension, edema, ventricular tachycardias, and atrial fibrillation.
- angina pectoris
- ischaemic heart disease.
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