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Wysolone, an artificial glucocorticoid analog, can be used mainly as anti-inflammatory or immunosuppressant agent.
Wysolone is indicated in the following conditions:
Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice: synthetic analogs may be used in conjunction with mineralcorticoids where applicable; in infancy mineralocorticoid supplement is of particular importance); congenital adrenal hyperplasia; non-suppurative thyroiditis; hypercalcemia associated with cancer.
As adjunctive therapy for short-term administration (to assist the patient during an acute episode or exacerbation) in: psoriatic arthritis; rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy); ankylosing spondylitis; acute and subacute bursitis; acute nonspecific tenosynovitis; acute gouty arthritis; post-traumatic osteoarthritis; synovitis of osteoarthritis; epicondylitis.
During an exacerbation or as maintenance therapy in selected cases of: systemic lupus erythematosus; acute rheumatic carditis; systemic dermatomyositis (polymyositis).
Pemphigus; bullous dermatitis herpetiformis; severe erythema multiforme (stevens-johnson syndrome); exfoliative dermatitis; mycosis fungoides; severe psoriasis; severe seborrheic dermatitis; lichen planus, unresponsive to local treatment.
Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment: seasonal or perennial allergic rhinitis; bronchial asthma; contact dermatitis; atopic dermatitis; serum sickness; drug hypersensitivity reactions.
Severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa such as: allergic conjunctivitis; keratitis; allergic corneal margin ulcers; herpes zoster ophthalmicus; iritis and iridocyclitis; chorioretinitis; anterior segment inflammation; diffuse posterior uveitis and choroiditis; optic neuritis; sympathetic ophthalmia.
Symptomatic sarcoidosis; loeffler??ôs syndrome not manageable by other means; berylliosis; fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy; aspiration pneumonitis.
Idiopathic thrombocytopenic purpura in adults; secondary thrombocytopenia purpura in adults; acquired (autoimmune) hemolytic anemia; erythroblastopenia (red blood cell anemia); congenital (erythroid) hypoplastic anemia.
For palliative management of leukemias and lymphomas in adults; acute leukemia of childhood.
To induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus.
To assist the patient during a critical period of the disease in: ulcerative colitis; regional enteritis.
Subacute hepatic necrosis: chronic active hepatitis; alcoholic hepatitis; non-alcoholic cirrhosis in women when ascites is not present.
Acute exacerbations of multiple sclerosis.
Tuberculosis meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculosis chemotherapy; trichinosis with neurologic or myocardial involvement; adjunctive therapy in severe typhoidal toxemia when the patient is responsive to conventional therapy; concomitantly with other immunosuppressive drugs to prevent rejection of transplanted organs.
Dosage and Administration
Dosage requirements are variable and must be individualized on the basis of the disease under treatment and the response of the patient. The initial dosage of wysolone may vary from 5 mg to 60 mg per day depending on the specific disease entity being treated.
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